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Insulin resistance, now linked to 31 different diseases, has been associated with increased odds of early death in women, according to a new study.
Insulin resistance, now linked to 31 different diseases, has been associated with increased odds of early death in women, according to a new study. Researchers, led by Jing Wu from Shandong Provincial Hospital in China, analyzed data from the UK Biobank, which includes genetic, medical, and lifestyle information from over 500,000 UK participants.
They used the TyG index, which measures insulin resistance by evaluating blood sugar and fat levels. The study revealed that higher TyG index scores, indicating greater insulin resistance, were common among older, less active, smoking men with obesity.
Over a median follow-up of 13 years, the study found that insulin resistance was linked to 31 diseases, including sleep disorders, bacterial infections, and pancreatitis. For women, each one-unit increase in insulin resistance was associated with an 11% higher risk of early death. Specifically, it was linked to an 18% higher risk of sleep disorders, an 8% higher risk of bacterial infections, and a 31% higher risk of pancreatitis.
No such link was observed in men. This study underscores the importance of assessing insulin resistance to identify individuals at risk for various health conditions, including obesity, hypertension, and heart disease.
